The enzyme 5α-reductase, which converts testosterone to dihydrotestosterone (DHT), performs key functions in the androgen receptor (AR) signaling pathway. The three isoenzymes of 5α-reductase identifi

Figshare2016-01-18 更新20

RNAseq PC3 DMSO vs GW3965. RNAseq PC3 DMSO vs GW3965

前列腺癌分子机制

单细胞RNA测序药物研究

Identify LXR target gens that are involved in migration and invasion phenotype Overall design: PC3 prostate cancer cell were treated for 24h with DMSO or GW3965 1µM in RPMI-1640, L-Glu 2mM after overn

NIAID Data Ecosystem10

Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence. Mus musculus

前列腺癌分子机制

信号通路靶向治疗

we evaluated the mechanism behind NOTCH activation in prostate cancer Overall design: GEP analysis of mice WT, Pten pc+/+; Ptenpc-/-; Ptenpc-/- treated with Gamma-secretase inhibitor

NIAID Data Ecosystem50

Circular RNA hsa_circ_0075542 acts as a sponge for microRNA-1197 to suppress malignant characteristics and promote apoptosis in prostate cancer cells

前列腺癌分子机制

环状RNA功能研究

Numerous differentially expressed circular RNAs (circRNAs) have been identified; however, their roles have not been fully elucidated. Since dysregulated circRNAs may have clinical applications, it is

Taylor & Francis Group2024-02-20 更新10

Transcription profiling of prostate cancer cells with Akt activation

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