Copper-Free Intramolecular Alkyne–Azide Cycloadditions Leading to Seven-Membered Heterocycles
收藏NIAID Data Ecosystem2026-03-07 收录
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资源简介：
Treatment of alk-2-ynyl derivatives of enantiopure phenylglycidol with NaN3 triggers a cascade reaction consisting of stereospecific and regioselective epoxide ring opening followed by intramolecular azide–alkyne cycloaddition under strictly metal-free conditions. This simple one-pot procedure allows a fast buildup of molecular complexity, generating a wide array of triazolooxazepinols, triazolodiazepinols, and triazolothiazepinols.
创建时间：
2016-02-22
