In vivo characterization of Linc-p21 reveals functional cis-regulatory DNA elements

We have sequenced wildtype and mutant heart, liver, lung, and hindlimb from E14.5 embryos of the mutant lncRNA strain Trp53cor1tm1.1Vlcg (lincp21), and performed a massively parallel reporter assay (MPRA) in mouse myoblast cells (C2C12). Comparison between wildtype and mutant organ transcriptomes in the Trp53cor1tm1.1Vlcg strain. Additionally, we include a comparison between MPRA signal vector tag distributions and C2C12 tag distributions.针对突变型长链非编码RNA（lncRNA）品系Trp53cor1tm1.1Vlcg（lincp21），我们对其胚胎发育第14.5天（E14.5）胚胎的野生型与突变型心脏、肝脏、肺脏及后肢组织完成了转录组测序，并在小鼠成肌细胞（C2C12）中开展了大规模平行报告基因检测（massively parallel reporter assay，MPRA）。针对该品系，我们开展了野生型与突变型各器官转录组的比较分析。此外，本数据集还包含MPRA信号载体标签分布与C2C12细胞标签分布的对比分析。