The microRNA profile of CAF derived exosomes under hypoxic and normoxic conditions.

Hypoxia commonly occurs in the tumor microenvironment (TME) during rapid tumor growth. Cancer-associated fibroblasts (CAFs) are the predominant cells in the TME. These CAFs are known to influence the progression of prostate cancer (PCa) via exosomes, with microRNAs being the principal non-coding RNAs present in these exosomes. In this project, we aim to investigate the specific microRNAs from CAFs that impact PCa progression in a hypoxic environment.