Crystal structure of estrogen receptor alpha in complex with receptor degrader 16ab

Crystal structure of estrogen receptor alpha in complex with receptor degrader 16ab Descriptor: (8R)-8-(4-{2-[3-(fluoromethyl)azetidin-1-yl]ethoxy}phenyl)-1,8-dihydro-2H-[1]benzopyrano[4,3-d][1]benzoxepine-5,11-diol, Estrogen receptor, GLYCEROL Authors: Kiefer, J.R, Vinogradova, M, Liang, J, Zhang, B, Ortwine, D.F, Nettles, K.W, Nwachukwu, J.C. Deposit date: 2018-05-14 Release date: 2019-02-20 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Unexpected equivalent potency of a constrained chromene enantiomeric pair rationalized by co-crystal structures in complex with estrogen receptor alpha. Bioorg. Med. Chem. Lett., 29, 2019