Mutation in the huntingtin (HTT) gene causes Huntingtonâs disease. Wild type Htt is essential for development as Htt knockout mice die at day E7.5. Increasing evidence suggests mutant Htt may alter
We have investigated the p53-dependent stress response in medium spiny neurons (MSNs) that degenerate in Huntington’s disease. To induce p53 signaling cascade, we have genetically inactivated by the C
The RNASeq Raw data related to the article of "Phosphorylation of myelin regulatory factor by PRKG2 mediates demyelination in Huntington's disease" Figure 4
Transcriptional dysregulation is an early feature of Huntington's disease (HD). We observed gene-specific changes in H3K4me3 at transcriptionally repressed promoters in R6/2 mouse and human HD brain.
