Structure of in-vivo formed alpha-synuclein fibrils purified from a M83+/- mouse brain injected with recombinant 1B fibrils

Structure of in-vivo formed alpha-synuclein fibrils purified from a M83+/- mouse brain injected with recombinant 1B fibrils Descriptor: Alpha-synuclein Authors: van den Heuvel, L, Burger, D, Kashyrina, M, de La Seigliere, H, Lewis, A.J, De Nuccio, F, Mohammed, I, Verchere, J, Feuillie, C, Berbon, M, Arotcarena, M, Retailleau, A, Bezard, E, Canron, M, Meissner, W.G, Loquet, A, Bousset, L, Poujol, C, Nilsson, K.P.R, Laferriere, F, Baron, T, Lofrumento, D.D, De Giorgi, F, Stahlberg, H, Ichas, F. Deposit date: 2025-07-15 Release date: 2025-07-30 Last modified: 2025-12-24 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Synthetic alpha-synuclein fibrils replicate in mice causing MSA-like pathology. Nature, 648, 2025