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In vivo prime editing in the liver using AAV vectors and lipid nanoparticle-mediated mRNA delivery

NIAID Data Ecosystem2026-05-02 收录

基因编辑递送

器官靶向基因治疗

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP428634 数据链接链接失效反馈

官方服务：

资源简介：

Improvement of in vivo prime editing in adult mouse livers

应用场景：

创建时间：

2024-07-01

髓鞘形成障碍

器官靶向基因治疗

Deficiency of arginase is associated with hyperargininemia, and unlike the other disorders of the urea cycle, the major mechanism of metabolism of nitrogen in terrestrial mammals, are characteristic a

NIAID Data Ecosystem90

Non-replicative phage particles deliverig CRISPR-Cas9 to target major blaCTX-M variants

基因编辑递送

抗微生物耐药性干预

blaCTX-M gene from this bacterial isolate was selected as a target for CRISPR-Cas9 system delivered by phage particles

NIAID Data Ecosystem60

AAV Delivery of intein-split base editors

基因编辑递送

碱基编辑技术

These data were generated by a series of experiments designed to optimized and validate base editing in vivo. We used protein inteins to split and deliver base editors, which are too large to be deliv

NIAID Data Ecosystem40

Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo

基因编辑递送

体内基因治疗

Prime editing enables precise installation of genomic substitutions, insertions, and deletions in living systems. Efficient in vitro and in vivo delivery of prime editing components, however, remain

DataCite Commons2026-01-29 更新60

In vivo delivery of prime editor protein and pegRNA via engineered virus-like particles

基因编辑递送

病毒样颗粒

HTS data associated with this publication

NIAID Data Ecosystem40