RNA-seq of human brain endothelial cells treated with Nrf2 activator RTA-404

Systemic inflammation can lead to a compromised blood-brain barrier (BBB) and neuro-inflammation, with acute consequences such as delirium, and long-lasting deleterious effects including cognitive decline and the exacerbation of neurodegenerative disease progression. Previous studies have shown beneficial roles of Nrf2 in the development and homeostastis of endothelial cells, an integral component of the BBB. We performed RNA-seq on human brain endothelial cells, in a control condition and treated with RTA-404 (CDDO-TFEA), a potent stimulator of Nrf2.