Inhibition of pyrimidine biosynthesis targets protein translation in AML [RNA-seq_RUNX1]
收藏NIAID Data Ecosystem2026-03-13 收录
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资源简介：
Investigation of the transcriptional profile of AML in response to DHODH inhibition by AG636. RUNX1-RUNX1T1 cells were transplanted into Ptprca recipients. Mice bearing tumors were treated with AG636 for one day. Leukemic stem cells (cKit high; CD11b low) from bone marrow and spleen were isolated and RNA sequencing performed. Overall design: Gene expression profiles of Vehicle or AG636 AML cells.
创建时间：
2022-07-21
