The role HOXA5 in extrahepatic cholangiocarcinoma (Expression)

Homeobox A5 (HOXA5) is a transcription factor in mammals and can regulate cell differentiation, proliferation and apoptosis as well as tumorigenesis. However, little is known about whether and how HOXA5 can regulate the malignant behaviors of cholangiocarcinoma. The expression profiles were analyzed by RNA microarray. We found MXD1 was upregulated upon HOXA5 overexpression. Besides, p53 pathway was activated by HOXA5 overexpression. Fresh cell samples of extrahepatic cholangiocarcinoma cell line TFK-1, containing three cell samples treated by HOXA5 overexpression vectors and three normal control samples.