TMC-95 based biphenyl-ether macrocycles: specific proteasome inhibitors

NIAID Data Ecosystem2026-05-01 收录

蛋白酶体抑制剂

大环化合物设计

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TMC-95 based biphenyl-ether macrocycles: specific proteasome inhibitors

创建时间：

2023-08-30

TMC-95 based biphenyl-ether macrocycles: specific proteasome inhibitors

蛋白酶体抑制剂

化学结构分析

TMC-95 based biphenyl-ether macrocycles: specific proteasome inhibitors Descriptor: BENZYL [12-(2-AMINO-2-OXOETHYL)-4-NITRO-10,13-DIOXO-15-[(PROPYLAMINO)CARBONYL]-2-OXA-11,14-DIAZATRICYCLO[15 .2.2.1~3

Protein Data Bank Japan2023-08-30 更新80

Structure-Based Design of β5c Selective Inhibitors of Human Constitutive Proteasomes

蛋白酶体抑制剂

结构导向药物发现

This work reports the development of highly potent and selective inhibitors of the β5c catalytic activity of human constitutive proteasomes. The work describes the design principles, large hydrophobic

Figshare2016-08-11 更新30

Planar Macrocyclic Fluoropentamers as Supramolecular Organogelators

超分子有机凝胶

大环化合物设计

Despite their great diversities, 2D-shaped macrocycles that can serve as the organogelators have been surprisingly rare; two planar macrocyclic fluoropentamers designed by us were highly able to gelat

Figshare2016-02-23 更新20

Yeast 20S proteasome with human beta5i (1-138) and human beta6 (97-111; 118-133) in complex with epoxyketone inhibitor 14

蛋白酶体抑制剂

蛋白质-配体复合物结构

Yeast 20S proteasome with human beta5i (1-138) and human beta6 (97-111; 118-133) in complex with epoxyketone inhibitor 14 Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, MAGNESIUM ION,

Protein Data Bank Japan2024-11-20 更新40

Yeast 20S proteasome mutant: beta5_T3M in complex with ONX0914

蛋白酶体抑制剂

结构生物学

Yeast 20S proteasome mutant: beta5_T3M in complex with ONX0914

NIAID Data Ecosystem20