cncRNAdb

RNA endowed with both protein coding and noncoding functions is referred to as “dual-function RNA”, “binary-function RNA” or “cncRNA (coding and noncoding RNA, was proposed by Dr. Karuna Sampath and colleagues)”. The discovery of cncRNA led researchers to reconsider the function, evolution and understanding of RNAs. Here, we developed cncRNAdb, a manually curated database of experimentally supported cncRNAs, which aims to provide a resource for efficient manipulation, browsing and analysis of cncRNAs. The current version of cncRNAdb documents about 2,600 manually curated entries of cncRNA functions with experimental evidence, involving more than 2,000 RNAs (including over 1,300 translated ncRNAs and over 600 untranslated mRNAs) across over 20 species. In summary, cncRNAdb provides a user-friendly interface to query and browse detailed information about these cncRNAs and will be of help in integrating, analyzing and predicting cncRNAs, enabling faster structural and functional research of RNA.同时兼具蛋白质编码与非编码功能的RNA，可被称为‘双功能RNA（dual-function RNA）’、‘二元功能RNA（binary-function RNA）’或‘编码非编码RNA（coding and noncoding RNA，由Karuna Sampath博士及其同事提出，简称cncRNA）’。cncRNA的发现促使研究人员重新审视RNA的功能、演化过程以及对RNA的认知。本研究开发了cncRNAdb，这是一个收录经实验验证的cncRNA、并经过人工整理注释的数据库，旨在为cncRNA的高效操作、浏览与分析提供数据资源。当前版本的cncRNAdb共收录约2600条经实验验证的cncRNA功能人工整理条目，涉及20余个物种的2000余种RNA，其中包含1300余种翻译型非编码RNA（translated ncRNAs）以及600余种非翻译型mRNA（untranslated mRNAs）。综上，cncRNAdb提供了便捷友好的界面，可用于查询和浏览这些cncRNA的详细信息，同时将有助于cncRNA的整合、分析与预测，从而推动RNA结构与功能相关研究的快速开展。

搜集汇总

背景与挑战

背景概述

cncRNAdb是一个手动整理、实验支持的双功能RNA数据库，收录了约2600个条目和超过2000种RNA，涵盖20多个物种。该数据库提供用户友好的界面，便于查询、浏览和分析这些RNA，以支持RNA结构和功能的快速研究。