Objective : Duchenne muscular dystrophy (DMD) is a devastating muscle disease caused by a mutation in DMD encoding dystrophin. Oxidative stress accounts for dystrophic muscle pathologies in DMD.

DataCite Commons2020-09-03 更新60

Genetic Modifiers of Duchenne Muscular Dystrophy and Dilated Cardiomyopathy

杜氏肌营养不良症

扩张型心肌病风险分层

ObjectiveDilated cardiomyopathy (DCM) is a major complication and leading cause of death in Duchenne muscular dystrophy (DMD). DCM onset is variable, suggesting modifier effects of genetic or environm

Figshare2016-01-15 更新20

Inhibition of BRD4 Rescues Cardiac phenotype in Myocyte-Specific Lamin A/C Null Mice

心脏疾病分子机制

基因治疗研究

Deletion of Lmna, encoding nuclear membrane protein LMNA, specifically in mouse cardiac myocytes activates BRD4 and leads to heart failure, arrhythmias, myocardial fibrosis, apoptosis, and premature d

NIAID Data Ecosystem60

scRNAseq RAT DIA WT and DMD 12months

单细胞转录组学

杜氏肌营养不良症

Duchenne muscular dystrophy (DMD) is a fatal muscle-wasting disorder caused by mutations in the Dystrophin gene with no therapeutic option. To bridge the gap between preclinical and therapeutic evalua

NIAID Data Ecosystem40

DMD monkey model generation and gene therapy

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