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Discovery and SAR Evolution of Pyrazole Azabicyclo[3.2.1]octane Sulfonamides as a Novel Class of Non-Covalent N ‑Acylethanolamine-Hydrolyzing Acid Amidase (NAAA) Inhibitors for Oral Administration
Inhibition of intracellular N-acylethanolamine-hydrolyzing acid amidase (NAAA) activity is a promising approach to manage the inflammatory response under disabling conditions. In fact, NAAA inhibition
NIAID Data Ecosystem70
Discovery of N ‑(1,3,4-Thiadiazol-2-yl)amide Derivatives as Uncompetitive Inhibitors of 6‑Phosphogluconate Dehydrogenase
6-Phosphogluconate dehydrogenase (6PGD) is a crucial enzyme in the pentose phosphate pathway and a promising target for oncotherapy. However, potent 6PGD inhibitors remain limited. Herein, we report a
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Patent AT-E401073-T1: [Translated] CYCLOALKYL-LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROIDDEHYDROGENASE 1
The present invention provides compounds of formula I that are useful as potent and selective inhibitors of 11-beta hydroxysteroid dehydrogenase 1. The present...
data.gov10
hKHK-C in complex with compound 28
hKHK-C in complex with compound 28 Descriptor: Ketohexokinase, SULFATE ION, [3-[[6-[(3~{a}~{R},6~{a}~{S})-2,3,3~{a},4,6,6~{a}-hexahydro-1~{H}-pyrrolo[3,4-c]pyrrol-5-yl]-3-cyano-4-(trifluoromethyl)pyri
Protein Data Bank Japan2024-09-04 更新50
Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with GDD-04-35
Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with GDD-04-35 Descriptor: 4-[(3-ethanoylphenyl)sulfamoyl]-~{N}-[4-(3-fluorophenyl)-1,3-thiazol-2-yl]benzamide, D-3-phosphoglycer
Protein Data Bank Japan2025-06-18 更新10
