Correlation between chemotype-dependent binding conformations of HSP90 alpha/beta and isoform selectivity Descriptor: 4-[6,6-dimethyl-4-oxidanylidene-3-(trifluoromethyl)-5,7-dihydroindazol-1-yl]-2-[(4

Protein Data Bank Japan2024-02-28 更新20

Pathway-based integrative analysis reveals a key role for the hexosamine biosynthetic pathway in castrate resistant prostate cancer with therapeutic implications. Homo sapiens

前列腺癌代谢重编程

己糖胺途径

The development and progression of castrate resistant prostate cancer (CRPC), a lethal disease, is thought to be driven by multiple events. A hallmark of CRPC is the ability to evade the cytotoxic eff

NIAID Data Ecosystem20

Dynamic interplay between sortilin and syndecan-1 has a role in the metabolic switch during prostate cancer progression

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去势抵抗性前列腺癌

Prostate cancer development and progression relies on the programming of glucose and lipid metabolism, and this involves alterations in androgen receptor expression and signalling. Androgen deprivatio

NIAID Data Ecosystem30

Nuclear mTOR acts as a transcriptional integrator of the androgen signaling pathway in prostate cancer progression [array]. Homo sapiens

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AR雄激素受体

Whether the nuclear fraction of mTOR plays a role in prostate cancer (PCa) and can participate in direct transcriptional crosstalk with the androgen receptor (AR) is as yet unknown. The intersection o

NIAID Data Ecosystem20

Table S3 from Fatty Acid Oxidation Is an Adaptive Survival Pathway Induced in Prostate Tumors by HSP90 Inhibition

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