Discovery of an Orally Bioavailable KRAS G12D Inhibitor
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Discovery of an Orally Bioavailable KRAS G12D Inhibitor Descriptor: (4P)-4-{1-[(1R,4R,5S)-2-azabicyclo[2.1.1]hexan-5-yl]-8-chloro-4-[3-(dimethylamino)azetidin-1-yl]-6-fluoro-1H-imidazo[4,5-c]quinolin-7-yl}naphthalen-2-ol, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... Authors: Deller, M.C, Epling, L.B. Deposit date: 2024-10-28 Release date: 2025-01-22 Last modified: 2025-02-05 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Discovery of INCB159020, an Orally Bioavailable KRAS G12D Inhibitor. J.Med.Chem., 68, 2025
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2024-10-28
