APOE3 genotype extends lifespan in rodent models of tauopathy

To gain insight into the role of human APOE on tau-associated neurodegeneration, we examined P301S mutant tau transgenic mice carrying humanized APOE alleles We performed gene expression profiling of the forebrains of P301S mutant tau transgenic mice carrying humanized APOE alleles alongside mice with humanized APOE alleles. Brains from mice that reached end stage phenotype (hindlimb paralysis) were collected.为深入解析人类载脂蛋白E（APOE）在tau相关神经退行性病变中的调控作用，我们以携带人源化APOE等位基因的P301S突变tau转基因小鼠为研究对象。同时，我们对携带人源化APOE等位基因的P301S突变tau转基因小鼠，以及仅携带人源化APOE等位基因的小鼠的前脑组织开展基因表达谱分析。本研究收集了达到终末期表型（后肢麻痹）的小鼠脑组织。