A) Genomic region showing dPNUTS locus flanked by dribble and ninaA. Coding regions of the genes is represented by shading. dPNUTS produces two transcripts dPNUTS and dPNUTS-S. ninaA is a non-essentia

NIAID Data Ecosystem60

Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1)

基因功能缺失表型分析

肾脏发育与免疫调节

Mice with inactivation of the gene encoding the suppressor of cytokine signaling-1 (SOCS-1) die in neonatal life with an IFN-γ-dependent inflammatory disease dominated by fatty degeneration and necros

PubMed Central2002-01-08 更新30

Stress-responsive pathways and small RNA changes distinguish variable developmental phenotypes caused by MSH1 loss. Arabidopsis thaliana strain:Col-0

植物胁迫响应

基因功能缺失表型分析

Loss of MSH1 causes an array of phenotypes, including variegation, dwarfism, altered leaf morphology, delayed flowering, and male sterility. Mutant individuals showing strong phenotypes are often more

NIAID Data Ecosystem60

CIL:28781

有丝分裂显微成像

基因功能缺失表型分析

Spinning disk confocal time-lapse imaging of the first mitosis in a C. elegans embryo expressing GFP-CeCENP-A in which KNL-2 has been depleted by RNAi. GFP-CeCENP-A was imaged (strain OD101). Diffuse

Figshare2016-01-11 更新50

Mice lacking DUF1220 protein domains are hyperactive and show reduced fecundity

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