Mouse infections with RNA viruses.

a1 day post-infection was reported to correspond to the peak of LDV replication and of IFN expression in vivo. bMice infected with highly neurovirulent viruses were sampled when signs of encephalitis were prominent (generally less than 24 hours before death). cThe DA1 strain of TMEV produces a transient encephalitis lasting about 1 or 2 weeks. In mice with the H-2 b haplotype, the virus is then rapidly cleared by the cytolytic T lymphocyte response [40],[41]. Mice were sampled at 5 days post-infection, a time-point representative of the acute phase of infection. dPreliminary RT-PCR experiments failed to reveal a clear difference in IFN expression and viral load between 129/Sv mice infected i.p. for 2 days and for 7 days. Only mice with amounts of MHV-A59 detectable by conventional RT-PCR were taken into account. eThese samples from TMEV (GDVII strain) and LACVdelNSs infected brains were from a previous work [33].