Gene expression in pediatric acute lymphoblastic leukemia patient-derived xenografts

ChEBI2015-10-24 更新2026-07-12 收录

白血病发病机制

患者源性异种移植模型

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-74299 数据链接链接失效反馈

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Gene expression in pediatric acute lymphoblastic leukemia patient-derived xenografts

创建时间：

2015-10-24

CXCL12/CXCR4 signaling mediates niche occupancy and tumor maintenance in T-cell leukemia

白血病发病机制

CXCR4靶向治疗

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy characterized by infiltration of the bone marrow and other sites with transformed T cell progenitors. The role of

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Gene expression profiling of CA10 and NHD13 murine AML

急性髓系白血病基因表达谱

白血病发病机制

We have compared the gene expression profiles of leukemic tissues in two different mouse models of AML, CALM-AF10 and NHD13, to clincally healthy transgenic and wildtype hematopoetic tissue to identif

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Functional Characterization of Cooperating MGA Mutations in RUNX1::RUNX1T1 Acute Myeloid Leukemia [ATAC-seq]

白血病发病机制

表观遗传调控

MGA (Max-gene associated) is a dual-specificity transcription factor that negatively regulates MYC-target genes to inhibit proliferation and promote differentiation. Loss-of-function mutations in MGA

NIAID Data Ecosystem30

Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia (RNA-seq of KLF6 KO)

造血干细胞表观遗传学

白血病发病机制

Aging is associated with functional decline of hematopoietic stem cells (HSC) as well as an increased risk of myeloid malignancies. We performed an integrative characterization of epigenomic and trans

NIAID Data Ecosystem50

Impaired proteolysis of non-canonical RAS proteins drives clonal hematopoietic transformation [scRNA-seq]. Impaired proteolysis of non-canonical RAS proteins drives clonal hematopoietic transformation [scRNA-seq]

白血病发病机制

RAS蛋白降解异常

Recently, screens for mediators of resistance to FLT3 and ABL kinase inhibitors in leukemia resulted in the discovery of LZTR1 as an adaptor of a Cullin-3 RING E3 ubiquitin ligase complex responsible

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Gene expression in pediatric acute lymphoblastic leukemia patient-derived xenografts

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