Human toxicogenomic studies to date have been of limited size, have mainly addressed exposures at the upper end of typical ranges of human exposure, and have often lacked precise, individual estimates
PPARα-null and wild-type male mice treated with PFHxS or PFNA Overall design: PPARα-null and wild-type male mice at 6-9 months of age were dosed by gavage for 7 consecutive days with either 0, 3, or 1
RNAseq of a novel hepatocyte subpopulation (Cxcr2hi) after acetaminophen exposure (300mg/kg) reveals distinct upregulation of genes involved in macrophage/neutrophil recruitment, specifically Cxcl14.