Genetically defined human GBM organoids reveal principles of GBM development and actionable targets. Genetically defined human GBM organoids reveal principles of GBM development and actionable targets

We used single cell RNA sequencing (scRNA-seq) to analysis the cellular state of organoids harboring different genetic mutations Overall design: scRNA-sequencing data for 1- and 4-month-old WT (wildtype), PT (PTEN-/-; TP53-/-), PTCC (PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-), and PTN (PTEN-/-; TP53-/-; NF1-/-) organoids samples