Although the DNA methylome of human early embryos has been analyzed, some of the key features have not been addressed to date. Here, we performed single-cell DNA methylome sequencing for human preimpl
TSA-NT differentially regulated genes. Breakdown of genes differentially up and downregulated with â Ľ1.5 fold change in TSA-NT compared to in vitro fertilized embryos. Red and green colors represent
Echs1 plays important roles in histone lysine crotonylation. Although it has been studied in many systems, its functions in early embryos remain unclear. In this study, we knocked down Echs1 in mouse
Upon fertilization, drastic chromatin reorganization occurs during human preimplantation development. However, the global chromatin landscape and its molecular dynamics in this period remain largely u
