Although the DNA methylome of human early embryos has been analyzed, some of the key features have not been addressed to date. Here, we performed single-cell DNA methylome sequencing for human preimpl
The early stages of mammalian embryonic development involve the participation and cooperation of numerous complex processes, including nutritional, genetic, and epigenetic mechanisms. However, in embr
The culture conditions of the early preimplantation embryos affects the DNA methylation landscape of the resulting blastocysts. Overall design: Five groups of blastocysts were generated. The first (ZY
The DNA methylation pattern in blastocyst that developed from oocytes exposed to the high level of NEFAs was investigated. Genome-wide DNA methylation analysis was performed by microarray using EDMA p
Imprinting describes the differential expression of alleles based upon their parent of origin. Deep sequencing of RNAs from maize endosperm and embryo tissue 14 days after pollination was used to iden
