Tests of association between SNPs and MS disease severity metrics.

MAF is the minor allele frequency. Fitted coefficients (coef) give the estimated change in disease severity metric for carriage of each additional minor allele. P-values arise from tests of whether these fitted coefficients differ significantly from zero. Symbol digit test (SDT) and intercaudate ratio (ICR) scores have been adjusted for disease duration. MSSS is the multiple sclerosis severity score. ICR is the intercaudate distance divided by the transverse skull diameter. Time 1& 2 is the time between the first demyelinating event and first relapse.