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资源简介：
mitochondrial DNA editing
应用场景：
创建时间：
2022-04-25
相关数据集
Engineering TALE-linked deaminases to facilitate precision adenine base editing in mitochondrial DNA
Programmable deaminases, including bacterial cytidine deaminase DddA-derived cytosine base editors (DdCBEs), zinc finger deaminases, and transcription activator-like effector (TALE)-linked deaminases
NIAID Data Ecosystem70
Knockout of CMS-causative mitochondrial gene. Oryza sativa
To determine whether a mitochondrial gene orf312 causes Tadukan-type cytoplasmic male sterility using mitochondrial-targeted TALEN
NIAID Data Ecosystem60
mitoTev‐TALE: a monomeric DNA editing enzyme to reduce mutant mitochondrial DNA levels
This work describes the development of a mitochondrial‐targeted DNA editing enzyme that can specifically cleave the MERRF m.8344A>G mtDNA mutation. The novel feature of this enzyme is that it is monom
HRA Figshare2026-03-16 更新30
MitoKO: A library of base editors for precise ablation of all protein-coding genes in the mouse mitochondrial genome
We design and apply a highly optimized library of double-stranded DNA deaminase (DddA)-derived cytosine base editors (DdCBEs) - MitoKO - to precisely ablate every mtDNA protein coding gene in the mous
NIAID Data Ecosystem70
Predictability of DdCBEs mediated base editing in mitochondrial DNA
DdCBE acts as the most commonly used editor for mtDNA, our understanding of the editing rules is very limited, especially for the aC targets, we need to optimize the editing strategies by adjusting th
NIAID Data Ecosystem40
