AGREE II scores for guidelines published pre and post formation of the GRC.¹

1Three additional guidelines were appraised, published since 2010 but known to have bypassed or not used the GRC approval process. These documents scored at levels similar to the pre-GRC guidelines and can be seen in Appendix S3. 2Each guideline was appraised by at least two assessors working independently and the individual scores aggregated. 3Mean scores were calculated across all ten guidelines for each domain. 4Scope and purpose concerns the overall aim of the guideline, the scope of the questions, and the target audience. 5Stakeholder involvement looks at the extent to which the guideline development process included the views of all appropriate stakeholders, including the intended users of the guideline and those affected by the recommendations. 6Rigour of development examines the process used to search for, synthesize, and appraise evidence, formulate recommendations, and keep them updated. 7Clarity of presentation concerns the general language, structure, and format of the guideline. 8Applicability requires adequate consideration of the likely barriers and facilitators to implementation, including resource considerations, and advice or tools to improve uptake and implementation. 9Editorial independence concerns the adequate declaration and management of potential conflicts of interest related to the funding body or the guideline group members.