zhang Hongxia -et-al-2021-circulating-pro-inflammatory-exosomes-worsen-stroke-outcomes-in-aging.pdf

Our data suggest that the levels of proinflammatory mediators in serum exosomes increase with age and are associated with worsened stroke outcomes through excessive C3aR-dependent microglial phagoptosis. Modulation of this process may serve as a promising therapy for stroke and other age-related brain disorders.