Structure of Human ROS1 Kinase Domain Harboring the G2032R Solvent-front Mutation in Complex with Zidesamtinib (NVL-520)

Structure of Human ROS1 Kinase Domain Harboring the G2032R Solvent-front Mutation in Complex with Zidesamtinib (NVL-520) Descriptor: 1,2-ETHANEDIOL, Proto-oncogene tyrosine-protein kinase ROS, Zidesamtinib Authors: Tangpeerachaikul, A, Mente, S, Magrino, J, Gu, F, Horan, J.C, Pelish, H.E. Deposit date: 2025-03-10 Release date: 2025-04-30 Last modified: 2025-07-16 Method: X-RAY DIFFRACTION (2.205 Å) Cite: Zidesamtinib Selective Targeting of Diverse ROS1 Drug-Resistant Mutations. Mol.Cancer Ther., 24, 2025