Extrachromosomal circular DNAs are ubiquitous in mouse hearts and function as enhancers to promote chromosomal transcription [Circle-seq]

To systematically analyzed the genome-wide characterization of potential eccDNAs in mouse heart tissues, we peformed Circle-seq in embryonic, neonatal and adult mouse heart tissues. Overall design: EccDNA expression profiling was analyzed to determine what extent eccDNAs occur in different developmental stages of mouse heart tissues (embryonic, neonatal and adult).