Enantioselective Syntheses of Spiroketals via a Tandem Reaction of Cu(I)-Catalyzed Cycloetherification and Hydrogen-Bond-Induced [4 + 2] Cyclization
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A tandem reaction consisting of a copper(I)-catalyzed cycloetherification and a hydrogen-bond-induced inverse-electron-demand oxa-Diels–Alder cycloaddition was performed from chiral propargyl alcohol, generating several kinds of optically pure [5, 6] spiroketals in excellent stereoselectivities and yields. The investigation on mechanism found that the cyclization prompted by a hydrogen bond not only improved the efficiency but also determined the diastereoselectivity.
创建时间：
2016-02-13
