Synthesis of Enantioenriched Allylic Silanes via Nickel-Catalyzed Reductive Cross-Coupling

An asymmetric Ni-catalyzed reductive cross-coupling has been developed to prepare enantio­enriched allylic silanes. This enantio­selective reductive alkenylation proceeds under mild conditions and exhibits good functional group tolerance. The chiral allylic silanes prepared here undergo a variety of stereo­specific transformations, including intramolecular Hosomi–Sakurai reactions, to set vicinal stereogenic centers with excellent transfer of chirality.