Uterine epithelial Gp130 orchestrates hormone response and epithelial remodeling for successful embryo attachment in mice

To investigate the molecular mechanism underlying Gp130-mediated LIF signaling in the endometrium during embryo implantation, we generated mice with uterine epithelium-specific deletion of Gp130. We report the sequencing of the uterine transcriptome of control and uterine epithelium-specific Gp130-deficient mice at day 4 (1600h) of pregnancy. Comparative gene expression profiling analysis of RNA-seq data for murine endometrium at day 4 (1600h) of pregnancy between control and uterine epithelium-specific Gp130-deficient mice.为探究胚胎着床过程中子宫内膜内Gp130介导的白血病抑制因子（LIF）信号转导的分子机制，我们构建了子宫上皮细胞特异性敲除Gp130的小鼠模型。本研究对妊娠第4天（16:00）的对照组与子宫上皮细胞特异性Gp130缺陷小鼠的子宫内膜转录组进行了测序，并针对该时间点两组小鼠的子宫内膜RNA测序（RNA-seq）数据开展了比较基因表达谱分析。