Transcriptome analysis of HPV transfected human trophoblast cells (JAR)

HPV is known to infect trophoblast cells. Downstream effects are however not studied well. This study aimed to investigate changes in the transcriptome of human trophoblasts after transfection of HPV16 E6 and E7, both seperately and in combination. The chorioncarcinoma cell line JAR was used as a model system. The overall goal was to investigate possible effects of HPV on pregnancy outcome after placental infection with HPV.