Activity of human neural crest enhancer near ZNF518B in E11.5 transgenic mouse embryo - Tg(hg38_chr4:10296754-10297578::LacZ).

Tg(hg38_chr4:10296754-10297578::LacZ) human neural crest enhancer with biased activity in the forebrain, midbrain, hindbrain, frontonasal process, periocular mesenchyme, cranial ganglia including at least the trigeminal (V) ganglion, maxillary and mandibular prominences of the 1st branchial arch, proximal forelimb bud, distal hindlimb bud, and dorsal root ganglia when compared to the orthologous chimp enhancer. Transgenic embryos also show reproducible activity in the 2nd branchial arch that overlaps with the chimp enhancer-driven lacZ expression, although X-Gal staining is stronger in human.