Stepwise differentiation of follicular helper T cells reveals distinct developmental and functional states
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2023-10-20
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Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro and in vivo follicular T helper cells.
Follicular T helper cells (Tfh) are critical for providing help to B cells for germinal center (GC) formation. Mutations affecting SAP prevent GC formation due to defective T:B cell interactions, yet
NIAID Data Ecosystem90
Genome binding/occupancy profiling of Zfp831-HA
Zfp831 is required for proper Tfh cell differentiation. In order to further understand the mechanisms whereby Zfp831 enhances Tfh differentiation, we conducted ChIP-seq analysis of Zfp831-HA Overall d
NIAID Data Ecosystem30
The transcription factor Mef2d regulates B:T synapse-dependent GC-Tfh differentiation and IL-21-mediated humoral immunity. The transcription factor Mef2d regulates B:T synapse-dependent GC-Tfh differentiation and IL-21-mediated humoral immunity
Comparison of transcriptome between PD1+CXCR5+ Tfh and PD1-CXCR5- non-Tfh compartments developed by control and Mef2d-RV OTII CD4 T cells Overall design: Control and Mef2d-RV CD45.1+ OTII CD4 T cells
NIAID Data Ecosystem20
Small RNA Deep Sequencing Analysis of Mouse T follicular helper (TFH) cells
Small non-coding RNAs, esp. microRNAs (miRNAs), play critical roles in a large diversity of biological processes. The goal of this study is to perfrom small RNA deep sequencing analysis of mouse T fol
NIAID Data Ecosystem30
Expression of germinal center T follicular helper (GC-Tfh) cells and pre-Tfh cells from tonsils (Tons) and follicular lymphoma lymph nodes (FL).. Expression of germinal center T follicular helper (GC-Tfh) cells and pre-Tfh cells from tonsils (Tons) and follicular lymphoma lymph nodes (FL).
GEP on Affymetrix Genechip HTA 2.0 microarrays was performed on ex vivo cell-sorted GC-Tfh and pre-Tfh from TONS and FL Overall design: GEP was performed on 3 GC-Tfh cell samples and 3 pre-Tfh cell sa
NIAID Data Ecosystem30
