Thermodynamic structural entropy, positional entropy, and corresponding Z-scores for a small collection of experimentally confirmed conformational switches, collected in [41]—sequences available at the RNAentropy web site.

For each sequence, the positional (resp. structural) entropy x was computed, along with the mean μ and standard deviation σ of 1000 dinucleotide shuffles of the sequence. The Z-score is then x-μσ. Dinucleotide shuffles were computed, using the Altschul-Erikson algorithm [42] as implemented in [43]. Pearson correlation between Z-scores for positional and structural entropy is 0.4103.