Reverse rate dependence is a problematic property of antiarrhythmic drugs that prolong the cardiac action potential (AP). The prolongation caused by reverse rate dependent agents is greater at slow he
In this study cardiac tissue is stimulated electrically through a small unipolar electrode. Numerical simulations predict that around an electrode are adjacent regions of depolarization and hyperpolar
Background and Objectives: Enhanced beat-to-beat variability of ventricular repolarization (BVR) has been linked to arrhythmias and sudden cardiac death. Recent experimental studies on human left vent
Changes in original Grandi et al. (GPB) [34] and O'Hara et al. (ORd) [35] models to simulate heart failure (HF) phenotype. The modified parameters are: the late Na+ current (INaL), the time constant o
The Right Atrium Affects In Silico Arrhythmia Vulnerability in Both Atria Authors: Patricia Martínez Díaz, Jorge Sánchez, Nikola Fitzen, Ursula Ravens, Olaf Dössel, Axel Loewe patricia.martinez@k
