Enantioselective Synthesis of Imidazolines with Quaternary Stereocenters by Organocatalytic Reaction of <i>N</i>-(Heteroarenesulfonyl)imines with Isocyanoacetates
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An organocatalytic enantioselective Mannich-type reaction of isocyanoacetate with N-sulfonylimines catalyzed by chiral thioureas derived from quinine yielded 2-imidazolines with high diastereo- and enantioselectivities (up to >99:1 dr. and 96% ee). This reaction provided a convenient route to access various imidazolines and related α,β-diamino acids having a quaternary carbon center in high enantiomeric purities.
创建时间：
2012-06-15
