Enantioselective Organocatalytic Tandem Michael−Aldol Reactions: One-Pot Synthesis of Chiral Thiochromenes
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A highly enantioselective (S) diphenylpyrrolinol silyl ether promoted tandem Michael−aldol reaction of α,β-unsaturated aldehydes with 2-mercaptobenzaldehydes has been developed. The method affords one-pot access to chiral and synthetically useful thiochromenes in high yields and high enantioselectivities from readily available compounds.
创建时间:
2006-08-16



