IDH1 R132H mutant in complex with IDH305
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IDH1 R132H mutant in complex with IDH305 Descriptor: (4R)-4-[(1S)-1-fluoroethyl]-3-[2-({(1S)-1-[4-methyl-2'-(trifluoromethyl)[3,4'-bipyridin]-6-yl]ethyl}amino)pyrimidin-4-yl]-1,3-oxazolidin-2-one, CITRATE ANION, Isocitrate dehydrogenase [NADP] cytoplasmic, ... Authors: Xie, X, Kulathila, R. Deposit date: 2017-09-15 Release date: 2017-11-08 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.334 Å) Cite: Discovery and Evaluation of Clinical Candidate IDH305, a Brain Penetrant Mutant IDH1 Inhibitor. ACS Med Chem Lett, 8, 2017
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2017-09-15
