PRC2 activates interferon-stimulated genes indirectly by repressing miRNAs in glioblastoma

Purpose: The goal of this study was to identify genes induced upon type I and II interferon response and how loss of PRC2/EZH2 impacts their induction. Methods: mRNA-seq from cells treated with universal type I IFN alpha/beta or IFN gamma. miRNA-seq from GBM-derived tumor samples. Overall design: mRNA-seq from cells treated with IFN alpha/beta or IFN gamma, each with two independent replicates.