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HDACi improves CRISPR-mediated base editing
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创建时间：
2020-05-27
相关数据集
Homo sapiens Genome sequencing. Homo sapiens
Recently, base editors, composed of cytidine deaminase, Cas9 nickase (nCas9), and uracil DNA glycosylase inhibitor (UGI), have recently been developed to substitute a C at a target site with T without
NIAID Data Ecosystem70
Homo sapiens and zebrafish Targeted Locus (Loci)
We find that pre-crRNAs comprising a full-length direct repeat (full-DR-crRNA) sequence with specific stem-loop G-C base substitutions exhibit increased editing efficiencies compared with the standard
NIAID Data Ecosystem30
Single CRISPR base editors to induce simultaneous C-to-T and A-to-G mutations
High-throughput sequencing data of CRISPR base editing assays in human cells
NIAID Data Ecosystem30
Highly efficient CRISPR-mediated base editing for the gut Bacteroides spp. with pnCasBS-CBE
We constructed a pnCasBS-CBE system for base editing in the Bacteroides thetaiotaomicron to expand their genetic toolkit, which can efficiently convert a C:G to a T:A in the genome. As a functional pr
NIAID Data Ecosystem40
Additional file 2 of Increased prime edit rates in KCNQ2 and SCN1A via single nicking all-in-one plasmids
Additional file 2: Table S1. Individual data values of all data represented in this manuscript.
Figshare2023-07-14 更新30
