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A damage independent role for 53BP1 that impacts break order and Igh architecture during CSR

ChEBI2016-06-16 更新2026-07-12 收录

抗体类别转换重组

基因组稳定性

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-81180 数据链接链接失效反馈

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A damage independent role for 53BP1 that impacts break order and Igh architecture during CSR

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创建时间：

2016-06-16

表观遗传调控

基因组稳定性

Histone H3.3 is a highly conserved histone H3 replacement variant in metazoans, and has been implicated in many important biological processes including cell differentiation and reprogramming. Germlin

NIAID Data Ecosystem80

DNA damage repair in barley following double-strand breaks and its dependence on ATR

DNA损伤修复

基因组稳定性

Maintaining genome integrity presents a particular challenge for plants due to their sedentary lifestyle, which disables direct avoidance of unfavorable external conditions. Additionally, plants’ meta

NIAID Data Ecosystem50

Whole-genome sequencing analysis of CRISPR-tolerant mutants. Escherichia coli

CRISPR系统

基因组稳定性

To investigate whether ISs transpositions into cas genes could potentially lead to concurrent transpositions into other genomic loci or induce genomic rearrangements and instability, we performed whol

NIAID Data Ecosystem40

A team of heterochromatin factors collaborates with small RNA pathways to combat repetitive elements and germline stress [ChIP-seq]

基因组稳定性

RNA调控机制

Repetitive sequences derived from transposons make up a large fraction of eukaryotic genomes and must be silenced to protect genome integrity. Repetitive elements are often found in heterochromatin; h

干细胞与再生医学数据中心2022-02-20 更新60

BLM prevents instability of structure-forming DNA sequences at common fragile sites

基因组稳定性

DNA修复

Genome instability often arises at common fragile sites (CFSs) leading to cancer-associated chromosomal rearrangements. However, the underlying mechanisms of how CFS protection is achieved is not well

Figshare2018-12-11 更新50

A damage independent role for 53BP1 that impacts break order and Igh architecture during CSR

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