We performed whole-genome sequencing (WGS) on human embryonic stem cells derived from human 8-cell embryos injected with or without FNLS-YE1, together with sgRNA that targeting PCSK9. Blood cell genom
We describe a robust linear amplification-mediated high-throughput genome-wide translocation sequencing (HTGTS) method that identifies endogenous or ectopic "prey" DNA double-stranded breaks (DSBs) ac
Gene editing technologies show great promise for application to human disease as a result of rapid developments in targeting tools notably based on ZFN, TALEN, and CRISPR-Cas systems. Precise modifica
Emerging base and prime editing may provide safer and more precise genetic engineering than nuclease-based approaches bypassing the dependence on DNA double strand breaks (DSBs). However, little is kn
