Despite the precipitous decline in the cost of genome sequencing over the last few years, library preparation for RNA-seq is still laborious and expensive for high throughput screening for drug discov
Human and Simian Immunodeficiency virus (HIV-1, HIV-2, and SIV) encode an accessory protein, Nef, which is a pathogenesis and virulence factor. Nef is a multivalent adapter that dysregulates the traff
A central aspect of inflammatory diseases is the influx of leukocytes into the affected site. Chemokine and their receptors are key regulator of leukocyte recruitment. Given the complexity of the chem
?Fit to internalization and β-arrestin 2 binding data with CXCL12 and CXCR4 in CXCR4+ cells. ??Fit to internalization and β-arrestin 2 binding data with CXCL12 and CXCR7 in CXCR7+ cells. *Reference gi
APE1 is the major nuclease for excising abasic (AP) sites and particular 3′-obstructive termini from DNA, and is an integral participant in the base excision repair (BER) pathway. BER capacity plays a
