HUMAN PI3KDELTA IN COMPLEX WITH ISOCUMARIN INHIBITOR 10

HUMAN PI3KDELTA IN COMPLEX WITH ISOCUMARIN INHIBITOR 10 Descriptor: 3-[(1S)-1-[4-azanyl-3-(3-fluoranyl-5-oxidanyl-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]ethyl]-4-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)isochromen-1-one, CHLORIDE ION, Phosphatidylinositol 3-kinase regulatory subunit alpha, ... Authors: Pala, D, Bruno, P, Capelli, A.M, Biagetti, M. Deposit date: 2024-08-05 Release date: 2024-12-18 Last modified: 2025-02-26 Method: X-RAY DIFFRACTION (2.81 Å) Cite: Discovery of CHF-6523, an Inhaled Selective PI3K delta Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease. J.Med.Chem., 68, 2025