Pancreatic islet epigenomics reveals enhancer clusters that are enriched in Type 2 diabetes risk variants. Pancreatic islet epigenomics reveals enhancer clusters that are enriched in Type 2 diabetes risk variants

We combined ChIP-seq of chromatin marks and key islet transcription factor with RNA-seq in human islets to map cis-regulatory networks in this primary tissue. The output of this project provides a reference map to dissect genetic variants that alter the susceptibility for Type 2 diabetes, and assist efforts to generate new beta-cells by transcriptional programming strategies