Single-cell and spatial transcriptomic profiling of human glioblastomas

This deposition includes scRNA-seq and Spatial Transcriptomics data for 24 GBM patients, which are categorized as follows: a) 7 patients with newly diagnosed GBM (ND group) b) 5 patients with recurrent GBM (Rec group) c) 12 patients who have undergone neoadjuvant therapy (Neo group). Additionally, this deposition contains scRNA-seq data for both wild-type (WT) and SiglecE knockout (KO) mice bearing intracranial CT2A glioma. The provided data includes both the raw matrix and the processed Seurat objects.

本存档数据集包含24例胶质母细胞瘤（Glioblastoma Multiforme, GBM）患者的单细胞RNA测序（single-cell RNA sequencing, scRNA-seq）与空间转录组学（Spatial Transcriptomics）数据，该患者队列分为以下三组：
a) 7例初诊胶质母细胞瘤患者（ND组）
b) 5例复发胶质母细胞瘤患者（Rec组）
c) 12例接受过新辅助治疗的胶质母细胞瘤患者（Neo组）
此外，本存档数据集还包含携带颅内CT2A胶质瘤的野生型（WT）与SiglecE基因敲除（KO）小鼠的scRNA-seq数据。本次提供的数据同时包含原始表达矩阵与预处理后的Seurat对象。