Next-generation sequencing analysis of 7-month-old SRSF2 flox/flox and SRSF2-PKO mice pancreatic islet transcriptome

We report insulin secretion defects in SRSF2 Ins2-Cre mice, in which SRSF2 is ablated in pancreatic cells. The control and SRSF2 Ins2-Cre gene in pancreatic cells mRNA profiles were generated by deep sequencing, using Illumina novaseq 6000.本研究报道了SRSF2 Ins2-Cre小鼠的胰岛素分泌缺陷表型，该模型中SRSF2在胰腺细胞中被敲除。研究通过Illumina NovaSeq 6000平台开展深度测序，获取了对照组与SRSF2 Ins2-Cre小鼠胰腺细胞的mRNA表达谱数据。